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KMID : 0359920070260030382
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Korean Journal of Nephrology
2007 Volume.26 No. 3 p.382 ~ p.385
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A Case of Acute Lithium Intoxication Treated with Continuous Venovenous Hemodiafiltration
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Ko Soon-Young
Seo Tae-Ho
Lee Seung-Min
Park Jung-Hwan
Jo Young-Il
Ryu Seung-Ho
Lee Jong-Ho
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Abstract
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Lithium is commonly used for the treatment of bipolar affective disorders. Lithium therapy has a narrow therapeutic window, which can lead to various neurologic, cardiovascular, and renal side effects. Dialysis is recommended for the treatment of severe lithium toxicity, but conventional hemodialysis can cause post-dialysis rebound of serum lithium level. We report a case of lithium intoxication in which continuous venovenous hemodiafiltration (CVVHDF) was successfully used in reducing toxicity. CVVHDF provides excellent lithium clearance, and prevents post-therapy lithium rebound by allowing a progressive removal of intracellular lithium. It could become a modality of choice for lithium intoxication.
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KEYWORD
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Lithium, Dialysis, Hemodiafiltration
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